GHRPs are a small family of peptides acting at the pituitary and the hypothalamus to release Growth hormone (GH) through the activation of a specific, G protein-coupled receptor. They were discovered 20 years ago as synthetic metenkephalin- derived oligopeptides. Although it has no structural homology with Growth Hormone Releasing Hormone (GHRH), in clinical studies GHRP-2 demonstrated action on the pituitary to release Human Growth Hormone (HGH). Similar results were effective when GHRP-2 was administered sublingual. Clinical studies showed the most potent GHRP being the hexapeptide GHRP-2.
GHRP-2 substantially stimulates the pituitary gland's increased natural production of the body's own endogenous human growth hormone. GHRP2 has shown on its own to robustly increase IGF-1 levels, and even greater results occurred when used with Growth Hormone Releasing Hormone to which also stimulates the pituitary gland to produce increased natural secretion of human growth hormone. This also boosts the hypothalamus function as well.
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